Tottenham coach Mauricio Pochettino has warned Manchester United that the Red Devils face a shock attempting to juggle Europa League and Premier League commitments.

United was eliminated in the Champions League group stage after it was beaten 3-2 by Group B winner Wolfsburg and PSV saw off CSKA Moscow on Tuesday.

Louis van Gaal and Co. are set to compete in the Europa League for the first time since 2011-12 and Pochettino said the Manchester club is in for a culture shock as it prepares for Thursday fixtures.

"It's a big, big difference," said Pochettino, whose Tottenham can win its Europa League group if it draws with Monaco on Thursday. "When you play Thursday and Sunday, it can affect the mentality and the psychology of the players. Thursday night, [long] travel and you need to play Sunday afternoon. Always for the player it affects them.

"Football is [supposed to be] Saturday 3 o'clock. It will be tough for them."

Pochettino added: "In Spain, for example, the clubs use the local competition to give players rest and recovery from the Champions League. For us, it's impossible. The Premier League is the toughest competition, this is the reality. Last weekend, Liverpool went to Newcastle and lost, Chelsea played Bournemouth and lost, Manchester City lost in Stoke — in Spain that wouldn’t happen."