Jacob Murphy, Harvey Barnes, Fabian Schar and Alexander Isak were on target for the Magpies, with Marc Guehi also scoring an own goal, as Newcastle made light of the absence of manager Eddie Howe due to pneumonia.

A sixth consecutive victory in all competitions opens up a five-point lead for Newcastle over sixth-placed Chelsea, with a place in the top five good enough for Champions League qualification.

Palace remain down in 12th with their season now fully focused on an FA Cup semi-final date with Aston Villa later this month.

Newcastle travel to Villa on Saturday in a huge clash in the battle for European places.

But the League Cup winners are pulling away from the chasing pack for a top-five finish, buoyed by ending their 70-year wait for domestic silverware last month.

"That gave us huge confidence," said Newcastle assistant manager Jason Tindall, who is was deputising for Howe, of lifting the League Cup.

"We were able to enjoy that for a period of time but we knew what our objectives were for the remainder of the season - to finish as high up the league table as possible.

"The manager always leads and sets that example of never switching off. They've gone out there, been really consistent and delivering performances."

Isak wasted two big early chances to open the scoring when he was firstly denied by a fine Dean Henderson save and then headed over from Murphy's enticing cross.

Newcastle only had to wait until the 14th minute to open the scoring when Murphy blasted in a remarkable finish from a narrow angle.

- Eze fluffs penalty -

Palace were gifted the chance to get back into the game when goalkeeper Nick Pope rushed off his line and wiped out Chris Richards in his attempt to punch the ball clear.

After a lengthy VAR check, a penalty was finally awarded.

However, Eberechi Eze's lackadaisical spot-kick was easily collected by the relieved Pope.

Within a minute, Newcastle had doubled their lead when Guehi turned into his own net as he attempted to block Barnes' cross towards Isak.

The England defender has been regularly linked with a move to Tyneside and has now scored an own goal in each of Palace's two meetings with Newcastle this season.

"There are some days where nothing works, and at the same time everything worked for Newcastle," said Palace boss Oliver Glasner.

"We couldn't deal with their intensity and directness and pace."

It went from bad to worse for the visitors as Barnes continued his fine form with a composed finish for his fourth goal in three games.

Murphy's free-kick was then flicked in by Schar to make it 4-0 before the break.

The normally lethal Isak continued to be frustrated in front of goal as Henderson spread himself to deny another effort from point-blank range early in the second half.

However, the Swedish striker finally got his 25th goal of the season with a fine finish from outside the area just before the hour mark.