The Columbus Crew's MLS Cup title defence came crashing to a halt as they were eliminated from the playoffs following a penalty shoot-out defeat to the New York Red Bulls.

Following a surprise home defeat in Game 1, Wilfried Nancy's champions needed a road win in Game 2 to keep their season alive, but Yevhen Cheberko, Max Arfsten and Alexandru Matan all saw their spot-kicks repelled by Carlos Coronel following a pulsating 2-2 draw.

Arfsten had earlier given Columbus a 55th-minute lead moments after stepping off the bench, only for Dante Vanzeir to drill home a swift equaliser.

New York looked set to advance when Emil Forsberg's 80th-minute penalty completed the turnaround, but another Crew substitute, Christian Ramirez, headed home six minutes into second-half stoppage time to force the shoot-out.

Columbus couldn't keep up their momentum from 12 yards, though, with Colonel's three saves proving vital as New York won it at the second time of asking, Daniel Edelman scoring the decisive kick after Sean Nealis had failed to do so.

Elsewhere, the Seattle Sounders also needed penalties to dump the Houston Dynamo out in round one, prevailing from the spot for the second game in a row.

Seattle's Cristian Roldan scored at both ends, slotting home an 87th-minute opener only to put through his own net three minutes into stoppage time, turning in Griffin Dorsey's cross.

The first 13 penalties in the shoot-out were all scored, but Tate Schmitt was the unfortunate man to see his spot-kick saved, Seattle goalkeeper Stefan Frei pushing it away to send his team to the Western Conference semifinals.

Finally, Ryan Gauld scored and forced two own goals as the Vancouver Whitecaps kept their best-of-three series against Los Angeles FC alive with a 3-0 triumph at BC Place.

The Scotland midfielder powered home after 10 minutes and, just 180 seconds later, saw his long-range effort deflected past Hugo Lloris by the unwitting Ryan Hollingshead.

Denis Bouanga twice went close for the Western Conference's top seeds after the break before Gauld was involved again in Vancouver's third goal, seeing a cross go in off the heel of Eddie Segura.

The teams will now reconvene for a third match next week, with the victors set to face Seattle in the next round.