Everton's miserable start to the new season continued as they were knocked out of the EFL Cup by Southampton, who experienced spot-kick joy after their penalty pain against Manchester United.

Sean Dyche's Toffees have lost their past two Premier League matches despite leading 2-0 in each, and they let slip another lead on Tuesday.

Abdoulaye Doucoure's opener was cancelled out by Saints' Taylor Harwood-Bellis, with a 1-1 draw taking the third-round tie to penalties at Goodison Park.

Southampton, like Everton, are pointless in the league after Cameron Archer's spot-kick miss in their latest defeat at home to United on Saturday proved costly.

But this time Saints succeeded from 12 yards, advancing after a 6-5 shoot-out win, with Ashley Young the only man to fail from the spot when Alex McCarthy saved the final kick.

That was one of three shoot-outs among Tuesday's cup matches, with Preston North End remarkably winning a marathon contest against Fulham.

Following another 1-1 draw, Preston were 16-15 victors on penalties as Timothy Castagne blazed the decisive effort over the crossbar after 17 attempts apiece.

Stoke City and Fleetwood Town also drew 1-1, before the Potters triumphed.

Elsewhere, Eberechi Eze netted the winner against former club Queens Park Rangers, with Eddie Nketiah also on target for the first time for Crystal Palace in a 2-1 victory.

Brentford came from behind to beat Leyton Orient 3-1, while Sheffield United defeated former boss Steve Bruce and Blackpool 1-0.