Efrain Alvarez's second-half strike proved enough for El Tri, who fielded eight debutants at Soldier Field.

Two of those debutants went close early on, Ricardo Monreal heading against the bar and Ettson Ayon testing Bolivia goalkeeper Carlos Lampe, while Ramiro Vaca fired over for the visitors later in the half.

However, the hosts did find the breakthrough within two minutes of the restart, as Monreal squared for Alvarez to control and finish.

El Tri, who will face Ecuador, Jamaica and Venezuela in Group B at the Copa America, will play Uruguay and Brazil before the tournament begins on 21 June (AEST).

Mexico is now unbeaten in each of its past 10 meetings with Bolivia, winning nine and conceding just two goals during that span.

A 3-1 reverse at the 1997 Copa America represents El Tri's only defeat in this fixture.