Uruguay's win saw it move level on points with host United States after its victory over Bolivia in the other Group C encounter. 

The 15-time winner was rewarded for its fast start when Maximilian Araujo curled home his first international goal in the 16th minute. 

However, Panama would grow into the contest as Jose Fajardo and Jose Rodriguez squandered golden opportunities for Thomas Christiansen's side. 

Panama's wastefulness was punished late on as Darwin Nunez, who had missed several chances in the game, settled Uruguay's nerves with a calm finish. 

Matias Vina furthered La Celeste's advantage in the first minute of injury-time with a header, only for Michael Amir Murillo to net a late consolation for Panama. 

However, Bielsa was quick to temper expectations despite the triumph, insisting his side must improve to secure a record 16th Copa America crown. 

The 68 year-old took charge of Uruguay in May last year, beating both Argentina and Brazil in World Cup qualifiers. 

"When it comes to Uruguay's aspirations, we will see that and build it match by match," Bielsa said. "My expectation is that each match will increasingly help us to improve on our level. Uruguay has players of a very good level and we need to see if I can build with those players."

Uruguay continues its group campaign against Bolivia in New Jersey on Thursday, before facing USA at the Arrowhead Stadium next week.